talk to sb意为：对某人讲话；talk with sb意为：某人一起交谈。talk to sb表示一个人要对另一个人讲话，但是不表示对方也需要讲话，主要是强调告诉某人什么事；talk with sb表达的是和某人一起谈论什么事物，双方都要发表言论，相互沟通。
talk to sb.与talk with sb.的区别
1、释义不同。
talk to sb意为：对某人讲话，还有责骂某人的意思。
talk with sb意为：某人一起交谈，还含有想说服某人的意思。
2、侧重点不同。
talk to sb 有点命令或者是告诉的意思，强调谈话的对象是“单向的”，如：I am talking to Tom.强调我单方面的对汤姆在谈话。
talk with sb 侧重两个人的一起互动，强调谈话的对象是 “双向的”，如：I am talking with Tom.强调我和汤姆在相互谈话、交流。
3、句型结构不同。
talk to sb一般会跟从句，如 I could always talk to you about anything in the world.（我总是可以和你谈论世界上的任何事情。）
talk with sb一般用在简单句，如I want to have a talk with him alone. （我想和他单独谈谈。）
talk to sb.与talk with sb.的例句
1、I want to have a talk with him alone.我要和他单独谈一谈。
2、I'll need to talk with you, but there's no hurry.我得和你谈谈，但不着急。
3、Before the wedding, I had a heart-to-heart talk with my mother.婚礼前，我和母亲好好谈了谈心。
4、One child shrinks away from me when I try to talk to him.当我试图和一个孩子说话时，他避开了我。
5、How many times has your mother told you never to talk to strangers?你母亲告诉你多少次了，绝不能和陌生人谈话？
6、If you hen to talk to him, have him call me.如果你碰巧能和他说话，让他给我打个电话。